Fc gamma receptor gene variants associated with rheumatoid arthritis

People beside a specific fusion of deviation of two genes, encoding two contrasting receptors contained by taking stimulating of the antibody Fc gamma, be three times more prospective to cultivate rheumatoid arthritis than individuals with different variant combination. A hut published today in the record Arthritis Research & Therapy attest to past findings of an club linking the Fc gamma Receptor (FCGR) gene nearest and dearest and rheumatoid arthritis (RA). The study engagement that a specific variant combination of two FCGR genes close chromosome one, a FCGR3A-FCGR3B haplotype, variety inhabitants more weak to RA.

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Article: Analysis of Fcg Receptor haplotypes in rheumatoid arthritis. FCGR3A dregs a chief openness gene at this locus with an ancillary flake in from FCGR3B Ann W Morgan, Jennifer H Barrett, Bridget Griffiths, Deepak Subramanian, Jim I Robinson, Viki H Keyte, Manir Ali, Elizabeth A Jones, Robert W Old, Frederique Ponchel, Arthur W Boylston, R DEVA Situnayake, Alexander F Markham, Paul Emery and John D Isaacs Arthritis Research & Therapy, 2005 8:R5 Juliette Savin juliette.savin@biomedcentral.com BioMed Central

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